1767 new VUS added in August 2025
Monthly refresh completed; expanded coverage for ocular and neuro panels.
Welcome to VUSkb
Knowledgebase of Variant of Uncertain Significance (VUS)
- —VUS
- —Genes
- —Diseases
Latest News & Events
Automated alert for VUS status now live
Subscribe to get notified whenever your tracked VUS changes classification in ClinVar.
61 VUS changed status
Weekly reclassification report based on ClinVar deltas and internal curation.